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Pertzye Warnings and Precautions

People who have problems with their kidneys or a history of bowel problems may not be able to safely use Pertzye. There are also some safety precautions for people who have high uric acid in the blood, as well as warnings for those who have gout. Some people may also have an increased risk for developing problems like allergic reactions and other dangerous complications.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Pertzye® (pancrelipase) if you have:
  • Gout
  • High uric acid in the blood (hyperuricemia)
  • Trouble swallowing capsules
  • Kidney disease, such as kidney failure, or if you are on dialysis
  • A history of intestinal blockage or other bowel problems
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Pertzye

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • Pancrelipase products such as Pertzye can cause a condition known as fibrosing colonopathy. This condition is potentially serious and may require surgery. It is most likely to occur with very high doses of Pertzye. Alert your healthcare provider to any symptoms of this condition, such as unusual or severe:
    • Bloating
    • Trouble passing stool
    • Abdominal (stomach) pain
    • Nausea, vomiting, or diarrhea.
  • Pertzye may increase uric acid levels in the blood, which may cause or worsen gout or kidney problems.
  • Make sure to swallow these capsules whole. For young children or other individuals with difficulty swallowing capsules, the contents can be sprinkled on a room-temperature acidic food (like applesauce) and swallowed without chewing. Do not chew the capsules or their contents. The small pellets in the capsules have a coating that helps protect the mouth from the drug, which can be very irritating.

    For people opening the capsules and sprinkling on food, always follow the dosage with juice or water. If mouth irritation occurs, let your healthcare provider know.
  • Pertzye is derived from the pancreatic glands of pigs. There is a theoretical possibility that the medication could contain viruses or other infectious materials from the pigs, although measures are taken to help prevent this. No cases of pig-related infections from Pertzye have ever been reported.
  • People who are allergic to pigs or pig products might also be allergic to Pertzye.
  • Pertzye is a pregnancy Category C medication, which means it may not be safe for use when pregnant, although the full risks are currently unknown (see Pertzye and Pregnancy).
  • It is not known whether Pertzye passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Pertzye and Breastfeeding).

Pertzye Medication Information

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