Cystic Fibrosis Home > Zenpep Dosage

The recommended Zenpep dosage will be calculated based on your age and weight, how you respond to the medication, and various other factors. Zenpep comes as an extended-release capsule and is usually taken with each meal. For young children or those who cannot swallow the capsules, the contents can be poured onto room-temperature applesauce (or other slightly acidic food) and swallowed.

An Introduction to Dosing With Zenpep

The dose of Zenpep® (pancrelipase) your healthcare provider recommends will vary, depending on the following factors:
  • Your age and weight
  • Your diet (especially how much fat you eat)
  • How you respond to the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
It should be noted that pancrelipase products, including Zenpep, are typically dosed based on lipase content, although they contain lipases, amylases, and proteases. 

What Is the Recommended Dosage of Zenpep for Adults?

The standard adult dosage for Zenpep varies, depending on the severity of pancreatic enzyme deficiency symptoms, weight, and previous response to similar medications. A reasonable starting dose is 500 units (based on lipase content) per kg of body weight, per meal (about 227 units of lipase per lb per meal). Your healthcare provider can increase your dose as needed. Typically, half the normal mealtime dose is used for snacks.

Zenpep Dosing Guidelines for Children

For infants (up to 12 months of age), the standard dose is one 3,000-unit Zenpep capsule (for each 120 mL of formula or breast milk ingested) before each bottle or each breastfeeding session.
For children age 12 months to 4 years of age, the standard starting dosage is based on age, usually 1,000 units (based on lipase content) per kg of body weight, per meal (about 455 units per lb per meal).
For children age 4 and older, a starting dose of 500 units (based on lipase content) per kg of body weight per meal (about 228 units of lipase per lb per meal) is recommended, with half the normal mealtime dosage used for snacks.
In all cases, your child's healthcare provider may adjust the dosage as necessary.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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