Cystic Fibrosis Home > Pertzye

Pertzye is prescribed to treat people who are deficient in pancreatic enzymes. Available as a delayed-release capsule, the medication is taken with each meal and snack. It works by providing the body with lipases, proteases, and amylases derived from the pancreatic glands in pigs. Although most people tolerate the drug well, side effects can occur and may include coughing, diarrhea, and heartburn.


What Is Pertzye?

Pertzye® (pancrelipase) is a prescription medication used to replace pancreatic enzymes (digestive enzymes secreted by the pancreas) in people with a deficiency of these enzymes. It is approved for use in people with cystic fibrosis or other conditions that cause pancreatic digestive enzyme deficiencies.
(Click Pertzye Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Pertzye is made by Digestive Care, Inc.

How Does Pertzye Work?

Pertzye contains a mixture of different pancreatic enzymes taken from the pancreatic glands of pigs. Specifically, it contains lipases, proteases, and amylases. Lipases help to digest fats, proteases help to digest proteins, and amylases help to digest starches.

When and How to Take It

Some general considerations to keep in mind during treatment with Pertzye include the following:
  • This medication comes in the form of a delayed-release capsule. It is usually taken by mouth with each meal and snack.
  • For small children or other individuals unable to swallow capsules, open the capsules and sprinkle the contents on a cold, slightly acidic food like applesauce. Swallow the applesauce completely and immediately, without chewing. Follow with water or juice.
  • Do not crush or chew the capsules, as this will destroy their extended-release properties and may cause mouth irritation.
  • For the medication to work properly, it must be taken as prescribed. Your symptoms will return if you stop taking Pertzye.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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