Cystic Fibrosis Home > Pertzye Uses

Pertzye is licensed to treat deficiencies in pancreatic enzymes that are caused by cystic fibrosis or certain other conditions. This prescription medicine contains enzymes derived from the pancreatic glands in pigs. It works by replacing the deficient enzymes, allowing food to be broken down properly and absorbed by the body. Pertzye is approved for use in children age 12 months and older.

What Is Pertzye Used For?

Pertzye® (pancrelipase) is a prescription medication approved to treat pancreatic enzyme deficiencies due to cystic fibrosis or various other conditions that affect the pancreas. Deficiencies of pancreatic enzymes are known as exocrine pancreatic insufficiency (EPI), as opposed to endocrine pancreatic problems, which affect hormones like insulin instead of enzymes. Pertzye contains pancreatic digestive enzymes derived from the pancreatic glands of pigs.

Understanding the Pancreas

The pancreas is an organ that has two general functions. It is probably most well known for its role in secreting insulin and other hormones. This is known as the endocrine (hormonal) function of the pancreas.
However, the pancreas has another very important role. It is responsible for producing several different digestive enzymes that help to break food down into smaller molecules that can be absorbed and used by the body. Various conditions can decrease pancreatic enzyme production. This can lead to malnutrition since the nutrients cannot be absorbed and also to digestive problems, such as diarrhea and fatty stools. Vitamin deficiencies may also occur.
Pertzye is used to replace the deficient digestive enzymes, allowing the food to be broken down and absorbed into the body.

How Does Pertzye Work?

Pertzye contains a mixture of different pancreatic enzymes taken from the pancreatic glands of pigs. Specifically, it contains lipases, proteases, and amylases. Lipases help to digest fats, proteases help to digest proteins, and amylases help to digest starches.
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Last reviewed by: Kristi Monson, PharmD;
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