Cystic Fibrosis Home > Bethkis

Bethkis is a medication prescribed to treat a certain bacterial infection in those who have cystic fibrosis. As an antibiotic, it works by interfering with bacteria's ability to grow and multiply. This medicine comes as a liquid that is used in a nebulizer and inhaled twice daily. Side effects may include worsening lung problems, abnormal breathing sounds, and a change in voice.


What Is Bethkis?

Bethkis® (tobramycin inhalation solution) is a prescription medication used to treat people with cystic fibrosis who have an infection in the lungs due to the bacteria Pseudomonas aeruginosa. It belongs to a group of antibiotics known as aminoglycosides.  
(Click Bethkis Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Bethkis is made by Catalent Pharma Solutions, LLC, for Cornerstone Therapeutics, Inc.

How Does Bethkis Work?

Bethkis works by killing bacteria. It does this by interfering with the bacteria's ability to make proteins, which are necessary for the bacteria to grow and multiply.

Clinical Effects

Bethkis has been studied in clinical trials that included people with cystic fibrosis who had an infection with the bacteria P. aeruginosa. People in the studies were randomly assigned to receive either Bethkis or a placebo (a fake medicine with no active ingredients).
In these clinical studies, Bethkis was shown to improve lung function more so than the placebo. Also, in one study, 9.9 percent of people treated with this drug had to be hospitalized due to their condition, compared to 24.7 percent of people given the placebo.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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