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Kalydeco Warnings and Precautions

If your healthcare provider recommends taking Kalydeco, it is important that you discuss whether you have any problems with your liver or kidneys. Other precautions for using Kalydeco safely include warnings of potential complications that may occur, such as drug interactions and allergic reactions. Also, women who are pregnant or nursing should discuss potential risks with their healthcare provider before taking this drug.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Kalydeco™ (ivacaftor) if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Kidney disease, such as kidney failure (renal failure)
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Kalydeco

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • Kalydeco can cause liver problems. In order to monitor for this, your healthcare provider should check your liver enzymes using a basic, standard blood test before you start Kalydeco, once every three months for the first year, and then annually thereafter.
  • Kalydeco may react with a number of medications. Some of these interactions can make Kalydeco less effective, while others increase the risk for Kalydeco side effects. Pay careful attention to these interactions and check with your healthcare provider or pharmacist any time you have a medication change (see Kalydeco Drug Interactions for more information).
  • Kalydeco is a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using this medicine during pregnancy (see Kalydeco and Pregnancy for more information).
  • It is unknown if Kalydeco passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start, make sure to talk with your healthcare provider about using Kalydeco (see Kalydeco and Breastfeeding for more information).

Kalydeco Medication Information

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