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Creon is a medication prescribed to increase pancreatic enzymes that may become low due to cystic fibrosis, pancreatitis, or certain other conditions. It contains a mixture of lipases, proteases, and amylases from the pancreatic glands in pigs. The drug comes as an extended-release capsule that is taken with each meal. Side effects may include coughing, dizziness, and vomiting.

What Is Creon?

Creon® (pancrelipase) is a prescription medication used to replace pancreatic enzymes (digestive enzymes secreted by the pancreas). It is approved for use in people who have cystic fibrosis, chronic pancreatitis, a completely or partially surgically removed pancreas, or certain other conditions.
(Click Creon Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Creon is made by Abbott Laboratories.

How Does Creon Work?

Creon contains a mixture of different pancreatic enzymes taken from the pancreatic glands in pigs. Specifically, it contains lipases, proteases, and amylases. Lipases help to digest fats, proteases help to digest proteins, and amylases help to digest starches.

When and How to Take It

Some general considerations to keep in mind during treatment with Creon include the following:
  • This medication comes in the form of an extended-release capsule. It is usually taken by mouth with each meal, or before each feeding for an infant.
  • For infants, the capsules should be opened and the contents poured directly into the mouth or onto a small amount of applesauce or commercially prepared pear or banana baby food. Follow immediately with formula or breastfeeding.
  • For small children or other individuals unable to swallow capsules, open the capsules and sprinkle the contents on room-temperature, slightly acidic food, such as applesauce. Swallow (without chewing) the applesauce completely and immediately. Follow with water or juice.
  • Do not crush or chew the capsules, as this will destroy the extended-release properties of the capsules and may cause mouth irritation.
  • For Creon to work properly, it must be taken as prescribed. Your symptoms will return if you stop taking this medication.

Creon Medication Information

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