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Creon Warnings and Precautions

People who have high uric acid levels in the blood or a history of intestinal blockage may have risks that prevent them from taking Creon safely. Other precautions for using this drug include warnings for women who are pregnant or nursing. To help ensure a safe treatment with this medication, make sure to discuss your complete medical history with your healthcare provider.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Creon® (pancrelipase) if you have:
  • Gout
  • Trouble swallowing capsules
  • High uric acid in the blood (hyperuricemia)
  • A history of intestinal blockage or other bowel problems
  • Kidney disease, such as kidney failure, or if you are on dialysis
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Creon

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • As with other pancrelipase products, Creon can cause a rare condition known as fibrosing colonopathy. This potentially serious condition may require surgery and is most likely to occur with high doses of Creon. Alert your healthcare provider to any symptoms of this condition, such as unusual or severe:
    • Abdominal (stomach) pain
    • Bloating
    • Trouble passing stool
    • Nausea, vomiting, or diarrhea.
  • Make sure to swallow Creon capsules whole. For babies, young children, or other individuals who have problems swallowing capsules, sprinkle the contents on room-temperature, acidic food like applesauce or commercially prepared pear or banana baby food, and then swallow it without chewing. Do not chew the capsules or their contents. The small pellets in the capsules have a coating that helps protect the mouth from the drug, which can be very irritating.
  • For people opening the capsules and sprinkling the contents on food, always follow the dosage with juice or water. If mouth irritation occurs, let your healthcare provider know.
  • Creon may increase uric acid levels in the blood, which may cause or worsen gout or kidney problems.
  • Creon is derived from pancreatic glands in pigs. There is a theoretical possibility that the medication could contain viruses or other infections from the pigs, although measures are taken to help prevent this. No cases of pig-related infections from Creon have ever been reported.
  • People who are allergic to pigs or pig products might also be allergic to Creon.
  • Creon is a pregnancy Category C medication, which means it may not be safe for use in pregnancy, although the full risks are currently unknown (see Creon and Pregnancy).
  • It is unknown whether Creon passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Creon and Breastfeeding).

Creon Medication Information

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