Creon comes as an extended-release capsule that is taken with each meal to help replace pancreatic enzymes that have become depleted due to certain medical conditions. The dosage of Creon your healthcare provider prescribes will depend on how old you are and how much you weigh, among various other factors. Because children may have problems swallowing the capsules, the contents can be poured out on applesauce and swallowed.
The dose of Creon® (pancrelipase) your healthcare provider recommends will vary, depending on the following factors:
- Your age and weight
- Your diet (especially how much fat you eat)
- How you respond to the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
It should be noted that pancrelipase products, including Creon, are typically dosed based on lipase content, although they contain lipases, amylases, and proteases.
The standard adult dosage for Creon varies, depending on the severity of pancreatic enzyme deficiency symptoms, weight, and previous response to similar medications. A reasonable starting dose is 500 units (based on lipase content) per kg of body weight, per meal (about 227 units of lipase per lb per meal). Your healthcare provider can increase this amount as needed. Typically, half the normal mealtime dosage is used for snacks.
For infants (up to 12 months of age), the standard dosage is one 3,000-unit Creon capsule before each bottle or each breastfeeding session. For children age 12 months to 4 years old, the standard starting dose is based on age, usually 1000 units (based on lipase content) per kg of body weight, per meal (about 455 units per lb, per meal).
For children age 4 and older, the starting amount is usually 500 units (based on lipase content) per kg of body weight, per meal (about 228 units of lipase per lb per meal), with half the normal mealtime dosage used for snacks.
In all cases, your child's healthcare provider may adjust this amount as necessary.