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Cayston Warnings and Precautions

If you have certain breathing problems and your healthcare provider recommends treatment with Cayston, you should understand that this drug may increase your risk for respiratory problems. This medicine can cause severe allergic reactions, severe breathing problems, and drug interactions in some people. To minimize your risk for problems, review the precautions and warnings for Cayston with your healthcare provider before starting treatment.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Cayston® (aztreonam for inhalation solution) if you have:
  • Breathing problems, such as wheezing, coughing, or chest tightness
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Cayston

Some warnings and precautions to be aware of prior to using this drug include the following:
  • Some people have had severe allergic reactions to this medication. People who are allergic to antibiotics called beta-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems, may also be allergic to Cayston. Let your healthcare provider know if you are allergic to other antibiotics. You should stop using Cayston and contact your healthcare provider immediately if you develop signs of an allergic reaction, such as:
    • A facial rash
    • Facial swelling
    • Chest tightness.
  • Cayston can cause the airways to constrict (tighten), which can lead to severe breathing problems, coughing, wheezing, or shortness of breath. To reduce the risk for this potential side effect, your healthcare provider will prescribe an inhaled bronchodilator to take before your Cayston dosage. Make sure you understand when and how to use your bronchodilator. Also, let your healthcare provider know if you experience symptoms of airway constriction during treatment.  
  • This drug is only approved to treat people with cystic fibrosis who are known to have a Pseudomonas aeruginosa infection. It should not be used in people with cystic fibrosis who do not have P. aeruginosa in their lungs. The drug will also not work to treat infections caused by viruses, such as the common cold. Using Cayston other than how it is prescribed could lead to the development of drug-resistant bacteria.
  • Forced expiratory volume in one second (FEV1) is the amount of air that can be forcibly exhaled from the lungs in the first second of a forced exhalation. It is used to measure lung function. You may experience an improvement in your FEV1 during the 28 days you are using Cayston. However, your FEV1 may decline when you stop treatment.
  • Cayston is a pregnancy Category B medication, which means it is likely safe for use during pregnancy (see Cayston and Pregnancy).
  • This medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to beginning treatment (see Cayston and Breastfeeding).

Cayston Inhaled Therapy Information

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